Amino Acids are the building blocks of protein. Protein makes up the substance and structure of muscle and other tissues or organs of the body. Hence, in order to synthesize more muscle tissue in response to training stress, or recovery from injury, the availability of amino acids in the diet is indispensable for everyday metabolic functioning and especially in supporting an active lifestyle.

The rationale lies in how the body regulates the rate of protein synthesis (such as building more muscle) and protein breakdown. The regulation is complex, but the idea is very simple. If your body has higher rates of protein synthesis and lower rates of protein breakdown, then in a given day, you have more protein synthesis in your body (in this case, you make more muscle). In other words, if you subtract the rates of protein synthesis minus the rate of protein breakdown and you get a positive (+) answer, then you have a (+) net protein balance. This simply means your body is retaining more protein than it gets rid of in any given day.

However, there has always been controversy as to the optimal amount of protein one should consume in a day. Athletes have always known that they need more protein than the typical “couch potato” but exactly how much has been controversial. The latest research has shown that increasing your protein intake does not necessarily mean you’ll increase protein synthesis. In fact, the body will increase the rate of protein breakdown if protein is consumed in excess. What is more crucial to having a positive (+) net protein balance in active individuals is the timing of nutrient intake around a training session.

Timing is one aspect but the athlete needs to consume specific nutrients in this time frame---mainly, essential amino acids. Essential amino acids or (EAA) are important around the workout period because the body is more likely to use (or utilize) these amino acids for protein accretion (build protein for muscles, from these amino acids). The word “Essential” means that the body needs to acquire these amino acids from the diet and cannot produce on its own. Amino acids that the body can produce de novo, literally from within the body without having to acquire it from the diet, are termed Nonessential Amino Acids (NEAA). Furthermore, EAA needs to be in bioavailable form, i.e. readily absorbed in the gut and into the bloodstream quickly to utilize this metabolic “window of opportunity” to build protein. Hence, the formulation intrinsic to Nitro-E8™ was created for this specific purpose.

Nitro-E8™ is rapidly absorbed and highly bioavailable---the amounts you take in by mouth is almost all absorbed and available in the bloodstream for muscles to grow and build protein in these crucial periods of exercise stress and during any stress for that matter, imposed on the body. Nitro-E8™ is almost like injecting amino acids into your bloodstream! Why are we so confident, because the specific ratios of amino acids in each tablet are the same ratios of amino acids found in human muscle! This is crucial since it is this ratio and the amino acid form that is supported in clinical studies for maximum bioavailability and utilization

Because of the unique formulation of Nitro-E8™, athletes or any active individual can reap the benefits of a (+) Nitrogen Balance, which include but not limited to:

Nitro-E8™ as a Stand Alone

Because Nitro-E8™ is in essence a “nitrogen” tablet” the optimal dosage is as much as you can afford. The more the better, however, we want to provide you a recommended minimum/maximum range that can be use to experience surprising results. The magic number has always been 10 tablets.

The suggested use is anywhere between 10 – 30 tablets based on bodyweight.

The above dosage was arrived at using the formula of weight in Kg x 0.2 tabs/kg.

First, convert your weight from pounds (lbs.) into kg by dividing weight in pounds by 2.2. For example, 220 lbs. = 220/2.2 = 100 kg.

To calculate your maximum tablets per day, multiply 100 kg x 0.2 tabs/kg = 20 tablets per day.

Training Days

The best recommendation is to avoid taking it on the days you don’t train and double up or increase dosage during the time it matters most – immediately after your workout. Otherwise, take half of the daily recommended dosage in the morning upon waking and take the other half before going to bed.

Note: if you do just cardio/aerobics on this day, take half of the daily dose in the morning upon waking up. The other half should be consumed post-cardio (NRG/HIIT –High Intensity Interval Training) session. In our 220 lbs example, 10 tablets should be consumed in the morning and the other 10 tablets either post-cardio session or before bedtime.

When formulating nutritional supplements in order to optimize their effectiveness, Physicians Pioneering Performance, LLC relies on the following principles/ guidelines:

A “supplement holiday” or OFF period of 2-3 weeks every 3 months is one method of optimizing supplement performance/efficiency over the long haul. This strategy falls under the umbrella of CHRONO-Nutrition™, and cyclical use of Nitro-E8™ to match training/ sport/ lifestyle demands. PPP has found that a 2 week taper prior to the 2-3 week OFF period with ½ the normal dose makes for an easier transition through the "supplement holiday" (e.g. with Nitro-E8™ taper, 2 servings of 0.075 grams per Kg bodyweight on training days; 1 serving of 0.075g/ Kg of bodyweight on off-days).

On the assumption that Nitro-E8™ is being used as a stand alone supplement, one may consider replacing it with a product like LeuceMine™ or CreaGen™ during the “supplement holiday”.

Before you try to understand how to stack or “polysupplement” Nitro-E8™ with other MNT products refer to the links above to review some of the terms (coined by PPP) used to describe the stacking concepts used with MNT products.

EAA - 10 tabs provides 13.5 grams total of the following amino acids:

Essential Amino Acids

Conditionally Essential Amino Acid

Non Essential Amino Acids

The key to Nitro-E8™ is the ratio of the above amino acids relative to each other. Hence, absorption from the gut is maximized and made available in the bloodstream for muscle cell absorption and utilization. The time from oral intake to utilization into muscle happens extremely fast in record time! It is available in the blood stream in as little as 5 minutes and ready for synthesis into muscle making it the fastest dietary protein source we know of. The reason is the high purity and crystalline form of the above amino acids in specific ratios as a whole and to each other. We don’t want to get into making ridiculous or unverifiable claims like, "...Nitro-E8™ increases Net Amino Acid Utilization (NAAU) by 5438%." What we can tell you is that based on our research and review of existing data, we find that the Nitro-E8™ formula in its precise ratios offers amongst the highest Net Amino Acid Utilization (NAAU) opportunities. Specially when compared to all other sources of dietary protein.

Moreover, the high NAAU and the relatively low calories inherent in the formulation compared to other protein sources, much less time is spent by the digestive system to process Nitro-E8™. The time from oral ingestion to utilization by muscles is in the order of minutes not hours compared to dietary meats, chicken, fish etc. As a means of comparison, red meat, poultry or fish can have an NAAU/ NNU 4 to 5 times LESS than Nitro-E8™. That means, as low as 20% to 30% of the amino acids from these protein sources are actually utilized by muscle. The other 70% to 80% of the amino acids provided are metabolic waste. You may have to eat 30 to 40 times the amount of dietary meats like poultry or fish to match the net utilization of amino acids inherent in only 10 tablets of Nitro-E8™!

Now to harness anabolic and/or anti-catabolic potential of Nitro-E8™, you need to consume it on an empty stomach and at specific time periods throughout the day. In other words, use CHRONO-Nutrition™, effective amino acid ratios and dosing strategies to overcome barriers that limit utilization by muscle tissue.

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