LeuceMine™ is a powerful formulation of L-Glutamine, and the BCAA: L-Leucine, L-Isoleucine, and L-Valine. Taken together, there is a body of scientific evidence supporting the diverse characteristics these amino acids possess. They exert;

These characteristics may assist athletes (recreational to elite) and fitness enthusiasts in their quest to maximize all the benefits of training.

Intense exercise induces a state of systemic and intramuscular L-Glutamine and BCAA depletion. Although there are limits to getting these amino acids into skeletal muscle to exert their effect, we use CHRONO-Nutrition™, effective amino acid ratios and dosing strategies to overcome these barriers. Ultimately, the components of LeuceMine™ will help optimize training adaptations by supporting metabolic recovery of energy stores (e.g. glycogen), stimulating muscle protein synthesis, minimizing muscle proteolysis (catabolism), and combating peripheral (muscular) and central (mental) fatigue.

How to Use LeuceMine™ By Itself

LeuceMine™ should be used as directed on TRAINING DAYS to begin at the onset of the exercise session. Consume the serving by sipping it throughout the workout, and finishing just prior to the end of the training session. We have observed that LeuceMine™ should be consumed a minimum of 5 days per week to optimize effectiveness. Therefore, if training occurs on a 4 day/ week schedule, an additional serving of LeuceMine™ should be consumed on an empty stomach prior to a meal on a NON-TRAINING DAY.

During TRAINING DAYS it is important that a dosage of at least 50% of what's taken during the workout is taken immediately after the last repetition of the last set.

When formulating nutritional supplements in order to optimize their effectiveness, Physicians Pioneering Performance, LLC relies on the following principles/ guidelines:

A “supplement holiday” or OFF period of 2-3 weeks every 3 months is one method of optimizing supplement performance/efficiency over the long haul. This strategy falls under the umbrella of CHRONO-Nutrition™, and cyclical use of LeuceMine™ to match training/ sport/ lifestyle demands. PPP has found that a 2 week taper prior to the 2-3 week OFF period with ½ the normal dose makes for an easier transition through the "supplement holiday" (e.g. with LeuceMine™ taper, 2 servings of 0.075 grams per Kg bodyweight on training days; 1 serving of 0.075g/ Kg of bodyweight on off-days).

On the assumption that LeuceMine™ is being used as a stand alone supplement, one may consider replacing it with a product like CreaGen™ or AntioxCene™ during the “supplement holiday”.

Before you try to understand how to stack or “polysupplement” LeuceMine™ with other MNT products, click here to review some of the terms (coined by PPP) used to describe the stacking concepts used with MNT products.

There are some performance nutrition advantages to consuming LeuceMine™ on NON-TRAINING DAYS, particularly during situations of extreme physiologic demand. Examples include but are not limited to: over-training, intentional over-reaching cycle followed by unloading/active rest block, increased training load and volume, multiple training/ strength and conditioning modalities (athletic/ sport skills + energy systems conditioning + strength training). These examples would fit within Nutritional Periodization, Nutrient Timing, and Restorative supplementation schemes of CHRONO-Nutrition™.

BCAA (L-Leucine in particular) in LeuceMine™ have the potential to "fortify" or "enhance" an otherwise inferior protein quality or quantity. In this scenario, 1 to 1.5 scoops would total 8 grams to 12 grams of the GlutaCene® proprietary blend to be consumed prior to a protein-containing meal on some NON-TRAINING days, or additional meals in the post-workout period on TRAINING days. When used with a Supplement Holiday and CHRONO-Nutrition™ to cycle its use up or down accordingly, LeuceMine™ becomes an extremely powerful adjunct to optimizing recovery and adaptation from the stimulus of exercise training

1) BCAA (L-L-Leucine) may act as strong insulin secretagogues, as such, they should not be consumed prior to large carbohydrate or fat loaded meals when trying to get lean.

2) In theory, the routine use of LeuceMine™ prior to workouts/ training may curtail and short-change L-Leucine's anabolic/ anti-catabolic properties by increasing its oxidation and breakdown. If L-Leucine is depleted and oxidized prematurely, then it will no longer be available during and immediately after the training session to "turn-on" protein synthesis and improve recovery.

3) When using an NO-product with any form of Arginine, some individuals may need to consume the NO-product 30-45 minutes prior to LeuceMine™ in order to space it out from the NO-product and maintain the "NO-response". Another option is to avoid the potential conflict by staggering their use depending on the particular workout. Training with high-intensity of effort, low-volume would be supplemented with the NO-product (to potentiate blood flow, "the pump") and LeuceMine™ would be used for the higher volume workout (since there will be stronger catabolic signals).

1) With High-Intensity/Abbreviated Interval Conditioning: Try using half the recommended amount of LeuceMine™ (usually comes to about 10-20grams) in 12-16oz of water and consume 1/2 of that total amount prior to starting your session. Then sip on the other half (remaining) throughout your "rest intervals" for the entire session (7 minutes - 25minutes). Then finish with 5-12 tabs of Nitro-E8TM (depending on your size) immediately post-NRG systems + 1/2 - 1/3 of your normal Post-Workout Carbohydrate Protein beverage within 30 minutes of completing your session.

2) With Steady-State NRG systems Conditioning: Try again mixing 1/2 of recommended LeuceMine™ (strength-power-resistance training) serving amount in ~12-16oz of water and sip throughout your session (25min-55min). Here an additional beverage to consider during your steady-state is to alternate your fluid intake with Green-Tea (1-2 tea bags in 6-10 oz of water in a sport bottle). Believe it or not you will still be able to steep the tea in cold water throughout your training session. Arguably, you could just consume a good metabolic activator/enhancer with EGCG green tea extract, but we are really impressed with some of the other benefits of the tea in its natural state with the tannins/small amount of caffeine/L-Theanine/catechin monomers/ etc. The hassle here is 2 water bottles (1 for LeuceMine™ and another for Green Tea), though the tea bottle is usually a lot smaller and not as cumbersome). Finish with the same immediate post-workout plan as above. Overall, this strategy really helps to emphasize the metabolic advantage/effect of your NRG systems conditioning.

Branched Chain Amino Acids (BCAA)

The BCAA component of LeuceMine™ provides a large array of benefits to any athlete or individual interested in making the most of their exercise/ training time and energy investment. The bevy of anabolic and performance effects include:

An interesting and unique feature of BCAA is their ability to bypass the gut and liver (as if they had "EZ Pass" direct ticket) en route to the skeletal muscle.

L-Leucine is considered an essential amino acid and one of the BCAA. Research data has accumulated to show that L-Leucine is the most critical of all the BCAA (and perhaps EAA) with respect to regulating and coordinating muscle protein synthesis. In many respects, L-Leucine appears to behave more like a hormone by intimately affecting intracellular signaling pathways independent, but in conjunction with insulin (the powerful anabolic hormone). Together with insulin, L-Leucine provides a "sensor" for skeletal muscle to modulate metabolism with exercise, training status, and energy balance (diet). L-Isoleucine and Valine are the other two amino acids that comprise the BCAA. Few studies have examined the effects of L-Isoleucine and L-Valine separately, although data supports that these BCAA are used preferentially in skeletal muscle as an energy source during intense exercise. Despite the relative importance of L-Leucine, the other BCAA are still considered essential amino acids that may be limiting protein synthesis if not provided along with L-Leucine. Additionally, the consumption of L-Leucine increases the demand for the other BCAA.

L-Glutamine is the most abundant amino acid in skeletal muscle and plasma, accounting for two-thirds of the amino acids inside skeletal muscle. Although the body usually synthesizes enough L-Glutamine to meet its basic needs, there are certain stressful, clinical situations that supersede the body's ability to meet demand. It has been established in the scientific literature that free intramuscular L-Glutamine levels are closely associated with protein synthetic rates, cellular volume, glycogen synthesis, and anti-catabolism. Heavy, intense training (such as with weight-lifting and resistance training sessions) results in L-Glutamine depletion, which seems to occur in at least 2 different phases (time-periods). The ability to synthesize enough L-Glutamine can be greatly overwhelmed during, immediately after, and 5-7 hours after intense training. This effect may be even more pronounced if anaerobic exercise/ resistance training occurs in the evening, as overnight fasting also causes L-Glutamine depletion. L-Glutamine is degraded during a training session due to the following:

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